Rapid and Reversible Chemical Inactivation of Synaptic Transmission in Genetically Targeted Neurons
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چکیده
منابع مشابه
Rapid and Reversible Chemical Inactivation of Synaptic Transmission in Genetically Targeted Neurons
Inducible and reversible silencing of selected neurons in vivo is critical to understanding the structure and dynamics of brain circuits. We have developed Molecules for Inactivation of Synaptic Transmission (MISTs) that can be genetically targeted to allow the reversible inactivation of neurotransmitter release. MISTs consist of modified presynaptic proteins that interfere with the synaptic ve...
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Introduction Synaptic plasticity mediates a variety of physiological functions, including emotional regulation, drug addiction, and learning and memory (Goelet et al., 1986). There are two temporally distinct forms of synaptic plasticity: short-term plasticity, which lasts seconds to minutes, and long-term plasticity, which lasts hours and days (Davis and Squire, 1984). Long-term plasticity dif...
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ژورنال
عنوان ژورنال: Neuron
سال: 2005
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2005.11.015